Cold Spring Harbor Laboratory Press

Informatics can vastly assist progress in research and development in cell and molecular biology and biomedicine. However, many investigators are either unaware of the ways in which informatics can...

One of the greatest medical accomplishments of the past century was the introduction of antibiotics into the clinic. However, the use of these lifesaving drugs rapidly led to the emergence of...

At the Bench is the unique and hugely successful handbook for living and working in the laboratory, an essential aid to understanding basic lab techniques and how research groups work at a human...

This handbook offers a practical guide to the principles of quantitative analysis in biological experiments. The material is primarily aimed at working molecular biologists, but the scope and clarity...

Cancer cells often display metabolic changes that distinguish them from normal cells in the body. Their preference for glycolysis over aerobic respiration even in the presence of oxygen was first...

Cytokines (e.g., interleukins and interferons) are small signaling proteins that are essential for communication between cells. They are important regulators of the immune system, helping to control...

Davenport's Dream: 21st Century Reflections on Heredity & EugenicsAuthor: Jan a. WitkowskiPublisher: Cold Spring Harbor Laboratory PressPublication Date: Mar 10, 2008Number of Pages: 490...

This is the second edition of a highly successful textbook (over 50,000 copies sold) in which a highly illustrated, narrative text is combined with easy-to-use thoroughly reliable laboratory...

Research on the fruit fly Drosophila melanogaster has played an important role in uncovering principles of nervous system structure and function. Fundamental insights include the first molecular...

The effective design and analysis of experiments in biology are critical to success, yet graduate students in biological and medical sciences typically receive very little formal training in these...

"Nobelist James D. Watson delves into his family history, exploring his ancestors' roots in Springfield, Illinois, and Chicago, and then focuses on his father James D. Watson, Sr., and his influence...

A second edition of the classic handbook has become a standard in the Drosophila field. This edition is expanded to include topics in which classical genetic strategies have been augmented with new...

Glia represent the majority of cells in the nervous system. Originally believed to be passive cells that support the neurons that transmit electrical signals, glial cells are now known to play a far...

The idea of a paradigm shift was initially presented in Thomas Kuhn's influential book The Structure of Scientific Revolutions (1962). Kuhn used this concept-the creation of a new world-view-to...

Since the appearance of modern humans in Africa around 200,000 years ago, we have migrated around the globe and accumulated genetic variations that affect various traits, including our appearance,...

Modern biotechnology--genetic engineering and cell manipulation--originated with the 1973 demonstration that genes from different organisms could be recombined and propagated in Escherichia coli...

The propagation of signals through the nervous system depends on rapid changes in electric potential across cell membranes. These changes are mediated by ion channels--macromolecular pores that...

We learn and remember information by modifying synaptic connections in the neuronal networks of our brain. Depending on the type of information being stored, these changes occur in different regions...

Methods in Yeast Genetics is a course that has been offered annually at Cold Spring Harbor Laboratory for the last 45 years. This is an updated edition of the course manual, which provides a set of...

Mitochondria are subcellular organelles that function as "power plants]for the cell, generating energy in the form of ATP from glucose, oxygen, and other molecules. Thought to have arisen about 2...

In this postgenome era, the large number of mouse mutations available is revolutionizing biomedical research. Large-scale mutagenesis projects have resulted in the modification of thousands of mouse...

Life arose on Earth more than three billion years ago. How the first self-replicating systems emerged from prebiotic chemistry and evolved into primitive cell-like entities is an area of intense...

This hugely influential book, published in 1966 as a 60th birthday tribute to Max Delbr?ck, is now republished as The Centennial Edition. On first publication, the book was hailed as "[introducing]...

Prions are best known as the agents of mad cow and related diseases, and a growing number of proteins with prion-like properties have been implicated in diseases such as Parkinson's. But some...

Diseases such as Creutzfeldt-Jakob disease and kuru develop when PrP proteins form prions by misfolding, clumping together, and spreading from cell to cell. Over the past decade, a number of proteins...

Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs...

Cells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex...

Synthetic biology involves the rational design and construction of biological components and systems--from genetic elements and metabolic pathways to entirely new organisms. Progress in this field...

Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in...

Lipids are the major component of cell and organelle membranes. They are essential for maintaining cell integrity and defining distinct subcellular compartments but also play important roles in a...