Alternative Splicing and Cancer

Alternative splicing is an essential post-transcriptional process of generating various protein isoforms of a single gene with distinct structural and functional properties. While changes in alternative splicing patterns play an important role in normal development and differentiation in response to physiological stimuli, but aberrant splicing generates variants that contribute to various human diseases, including Parkinson's disease, cystic fibrosis, spinal muscular atrophy, and importantly cancer etc. Differential expression or activities of various alternative splicing regulatory factors generate alternatively spliced transcripts that contribute to the formation of aggressive tumors by regulating many cellular processes including cell proliferation, survival, angiogenesis, immune escape, invasion & metastasis, and development of resistance to therapeutics. Comprehensive analysis of aberrant alternative splicing networks and cancer-associated alternative splicing isoforms will help better understand the fundamental hallmarks of cancer and offer new opportunities for the identification of diagnostic, prognostic targets with improved anti-cancer treatments efficacy--

Author: Muzafar Ahmad Macha, Surinder K. Batra, Ajaz A. Bhat

Publisher: CRC Press

Publication Date: May 03, 2024

Number of Pages: NA pages

Language: English

Binding: Hardcover

ISBN-10: 1032196599

ISBN-13: 9781032196596