Humana
G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders
Product Code:
9781489942906
ISBN13:
9781489942906
Condition:
New
$180.44
G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders
$180.44
The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G, G, G, and G12.
| Author: Ram K. Mishra |
| Publisher: Humana |
| Publication Date: Aug 16, 2013 |
| Number of Pages: 433 pages |
| Binding: Paperback or Softback |
| ISBN-10: 1489942904 |
| ISBN-13: 9781489942906 |
