A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.
| Author: Charles J. Hackett |
| Publisher: Humana |
| Publication Date: Dec 09, 2010 |
| Number of Pages: 284 pages |
| Binding: Paperback or Softback |
| ISBN-10: 1617372404 |
| ISBN-13: 9781617372407 |
