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Caister Academic Press Limited

Alphaherpesviruses: Molecular Virology

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Product Code: 9781904455769
ISBN13: 9781904455769
Condition: New
$250.00
$242.24
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Alphaherpesviruses: Molecular Virology

$250.00
$242.24
Sale 3%
 

Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.




Author: Sandra K. Weller
Publisher: Caister Academic Press Limited
Publication Date: Mar 01, 2011
Number of Pages: 460 pages
Binding: Hardback or Cased Book
ISBN-10: 190445576X
ISBN-13: 9781904455769
 

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