Malaria Parasites: Comparative Genomics, Evolution and Molecular Biology

Since the publication of the first two Plasmodium genome sequences in 2002, numerous other parasite genomes have been sequenced. These include the genomes of several more Plasmodium species, as well as those of other apicomplexans, including species of Toxoplasma, Cryptosporidium, Babesia, and Eimeria. This wealth of genome sequence data has provided researchers with a powerful new tool, comparative genomics, which has revolutionized research in this area. In this book, expert contributors from around the world comprehensively review the current advances in Plasmodium comparative genomics, highlighting the fascinating new insights into parasite evolution and molecular biology that have ensued. Topics include: Plasmodium taxonomy and phylogeny * the apicomplexan genomic landscape * the "art" of sequencing Plasmodium genomes * diversity of Plasmodium falciparum and Plasmodium vivax genomes * Plasmodium functional genomics * Plasmodium experimental genetic crosses * P. falciparum epigenetic modification and transcriptional regulation * Plasmodium invasion of host red blood cells * protein export and trafficking by malaria parasites * Plasmodium-mosquito vector interactions * a practical guide to many of the revolutionary new techniques and molecular tools for Plasmodium research. The book will be essential reading for all researchers working with malaria parasites and related organisms - from the PhD student to the experienced scientist - and is a recommended text for all parasitologists.