Springer
Regulatory Genomics: Recomb 2004 International Workshop, Rrg 2004, San Diego, Ca, Usa, March 26-27, 2004, Revised Selected Papers
Product Code:
9783540244561
ISBN13:
9783540244561
Condition:
New
$61.47
Regulatory Genomics: Recomb 2004 International Workshop, Rrg 2004, San Diego, Ca, Usa, March 26-27, 2004, Revised Selected Papers
$61.47
Research in the ?eld of gene regulation is evolving rapidly in an ever-changing s- enti?c environment. Microarray techniques and comparative genomics have enabled more comprehensive studies of regulatory genomics and are proving to be powerful tools of discovery. The application of chromatin immunoprecipitation and microarrays (chIP-on-chip) to directly study the genomic binding locations of transcription factors has enabled more comprehensive modeling of regulatory networks. In addition, c- plete genome sequences and the comparison of numerous related species has dem- strated that conservation in non-coding DNA sequences often provides evidence for cis-regulatory binding sites. That said, much is still to be learned about the regulatory networks of these sequenced genomes. Systematic methods to decipher the regulatory mechanism are also crucial for c- roboratingthese regulatorynetworks.Thecoreof thesemethodsarethe motifdiscovery algorithms that can help predict cis-regulatory elements. These DNA-motif discovery programsarebecomingmoresophisticatedandare beginningto leverageevidencefrom comparative genomics (phylogenetic footprinting) and chIP-on-chip studies. How to use these new sources of evidence is an active area of research.
| Author: Eleazar Eskin |
| Publisher: Springer |
| Publication Date: Feb 16, 2005 |
| Number of Pages: 116 pages |
| Binding: Paperback or Softback |
| ISBN-10: 3540244565 |
| ISBN-13: 9783540244561 |
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