VDM Verlag Dr. Mueller E.K.
Scope and Limitations of the T-Reaction
Product Code:
9783639032819
ISBN13:
9783639032819
Condition:
New
$85.32
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Scope and Limitations of the T-Reaction
$85.32
$83.05
Sale 3%
The quinoline motif is an integral part of a wide variety of bioactive classes of compounds. An increasingly popular entry into tetrahydroquinolines is represented by the T-reaction, i.e. a subtype of the transformations relying on the isomerization-cyclization sequence known as the tert.-amino-effect. The latter was shown to proceed via a most remarkable helical dipolar intermediate generated upon a hydrideshift from an alpha-amino-C-H in tert.-anilines to an unsaturated ortho-substituent, accomplishing C-C-bond formation from a nonactivated NCH-moiety. The tert.-amino-effect was first brought to the attention of the synthetic community in the seminal contribution of O. Meth-Cohn and H. Suschitzky from 1972. Since then, the protocol has progressively evolved into a convergent, economical and yield-efficient preparation of structurally diverse, highly functionalized and pharmacologically valuable heterocycles, bearing stereoselectively introduced centers of chirality.
| Author: Constantin Rabong |
| Publisher: VDM Verlag Dr. Mueller E.K. |
| Publication Date: May 16, 2008 |
| Number of Pages: 204 pages |
| Binding: Paperback or Softback |
| ISBN-10: 3639032810 |
| ISBN-13: 9783639032819 |
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