The objective of this work was to evaluate the suitability of in situ forming biodegradable microparticles for the controlled delivery of proteins. Particular goals were: a) to evaluate the flexibility of the release patterns of in situ implant and in situ microparticle formulations using hen egg white lysozyme as model protein; b) to characterize, if and how the integrity of the model protein is affected by formulation ingredients, the manufacturing process, sto-rage of the ISM and the release from the formulations; c) to optimize protein delivery from in situ forming implant and microparticle systems, with regard to shape and completeness of the release; d) to find / validate reliable methods allowing to extract and thus to characterize the model protein in biodegradable in situ formulations.
| Author: Martin K?ber |
| Publisher: VDM Verlag Dr. Mueller E.K. |
| Publication Date: Aug 22, 2008 |
| Number of Pages: 332 pages |
| Binding: Paperback or Softback |
| ISBN-10: 3639076591 |
| ISBN-13: 9783639076592 |
