Formulation Development and Characterization of Nanosuspension

This study was to identify and optimize formulation and process variables affecting characteristic and scale-up of nanosuspension manufacturing process on bead mill i.e media milling buttom down technique considering industrial perspective. Formulation factors evaluated were ratio of different polymer to drug and to beads. Whereas process parameters were milling bead concentration and stabilizer concentration. Responses measured in this study include zeta potential and mean particle size. The test revealed that ratio of polymer to drug have significant effect on zeta potential whereas variable milling bead concentration at constant milling speed and milling time have significant effect on the particle size distribution of nanosuspension. The X-ray powder diffraction pattern of drug milled at high and low speed reveals no form conversion when compared with unmilled drug. The formulated nanosuspension has shown a faster % cumulative release.

Author: Asit Ranjan Sahu

Publisher: LAP Lambert Academic Publishing

Publication Date: Sep 04, 2019

Number of Pages: 88 pages

Binding: Paperback or Softback

ISBN-10: 6200306567

ISBN-13: 9786200306562