Our Knowledge Publishing
New route to the synthesis of chiral 1,2,4-oxadiazin-5-ones
Product Code:
9786207924332
ISBN13:
9786207924332
Condition:
New
$48.72
New route to the synthesis of chiral 1,2,4-oxadiazin-5-ones
$48.72
The research work carried out in this book aims to develop a simple and rapid synthesis route for new chiral derivatives of 1,2,4-oxadiazin-5-ones known for their interesting biological activities.The first part of this book describes the synthesis of a series of optically active α-bromoacids by enantioselective nitrous deamination of natural amino acids. These will subsequently react with thionyl chloride followed by methanol to give the corresponding α-bromoesters.Condensation of these previously prepared α-bromoesters with 1-benzenesulfonylpyrrolidin-2-carboxamidoxime in the presence of two equivalents of sodium hydride offers desired new chiral 1,2,4-oxadiazin-5-ones in good chemical yields.
| Author: Najeh Tka |
| Publisher: Our Knowledge Publishing |
| Publication Date: Aug 08, 2024 |
| Number of Pages: 56 pages |
| Binding: Paperback or Softback |
| ISBN-10: 6207924339 |
| ISBN-13: 9786207924332 |
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