Springer
New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations
Product Code:
9789811028984
ISBN13:
9789811028984
Condition:
New
$117.02
New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations
$117.02
This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and a,ß-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4] annulation of ß-substituted nitroalkenes. The scope of Rauhut?Currier reaction was successfully extended to the most challenging ß-substituted alkenes by this method; (2) Enals were successfully used for [4] annulations with azodicarboxylates catalyzed by NHC via ?-addition. Highly enantiopure tetrahydropyridazinones and ?-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available a,ß-unsaturated carboxylic acids were first successfully employed to generate the a,ß-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3] and [3] annulations.
| Author: Xiangyu Chen |
| Publisher: Springer |
| Publication Date: Dec 30, 2016 |
| Number of Pages: NA pages |
| Language: English |
| Binding: Hardcover |
| ISBN-10: 9811028982 |
| ISBN-13: 9789811028984 |
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