The Base Excision Repair Pathway : Molecular Mechanisms and Role in Disease Development and Therapeutic Strategies

Genomic uracil : dangers and benefits in processing / Hans Krokan -- The GO repair pathway : OGG1 and MUTYH / Sheila David -- The DNA glycosylases that recognize and remove free radical-damaged pyrimidines / Susan Wallace -- Alkyladenine DNA glycosylase / Leona Samson -- The abasic endonuclease APE1 : much more than a DNA repair enzyme / Gianluca Tell -- Central steps in mammalian BER and regulation by PARP1 / Samuel Wilson -- Processing strand break termini in the DNA single strand break repair pathway / Michael Weinfeld -- The PARP-XRCC1 axis in base excision repair / Janet Hall -- DNA ligases in base excision repair / Alan Tomkinson -- Base excision repair and epigenetic regulation / Primo Schär -- Base excision repair in the immune system / Carol Schrader -- Base excision repair in the etiology of lupus and cancer / Joann Sweasy -- Base excision repair in trinucleotide repeat expansion disorders / Margherita Bignami -- Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases / Yusaku Nakabeppu -- Assessing BER capacity in the human population / Zachary Nagel -- Prognostic and predictive significance of base excision repair in human cancers / Srinivasan Madhusudan -- Enzymes in the base excision repair pathway as targets for small molecule mediated therapeutics / R. Stephen Lloyd -- Mitochondrial base excision repair / Nadja de Souza Pinto -- Base excision repair in aging / Tinna Stevnsner

Author: David M. Wilson

Publisher: World Scientific Publishing Company

Publication Date: Feb 09, 2017

Number of Pages: 350 pages

Language: English

Binding: Hardcover

ISBN-10: 9814719722

ISBN-13: 9789814719728