Molecular Modelling of Vitamin B12 and Its Analogues

For many years, the chemistry of vitamin B12 and its derivatives has been investigated for their inherent eco-friendly and nontoxic nature. This vitamin, also known as cobalamin, is an organic complex that contains a cobalt ion in its structure. Its derivatives are vital bio-inorganic cofactors and possess complex and rich photolytic properties, facilitated by their excited states. Several studies in the field of organic chemistry have effectively applied vitamin B12 as a catalyst in various organic reactions such as 1,4-additions to activated double bonds, alkyl and aryl halide dimerization, dehalogenation, and hydrogenation of double bonds. The story of vitamin B12 analogues has opened doors for exploring other large ring-type structures that can be used for designing drug delivery systems and synthesising smart biological materials. This book compiles and details cutting-edge research in the application of vitamin B12 as an environmentally benign catalyst for several organic reactions. It discusses the recent advances and current understanding of the photolytic properties of vitamin B12 derivatives from the perspective of the density functional theory. The book is of interest for anyone involved in nanotechnology, macromolecular science, cancer, and drug-delivery research.

Author: Penny Govender, Taylor & Francis Group, Francis Opoku, Olaide Wahab, Ephraim Kiarii

Publisher: Taylor & Francis Limited (Sales)

Publication Date: Sep 24, 2021

Number of Pages: 164 pages

Language: English

Binding: Hardcover

ISBN-10: 9814877581

ISBN-13: 9789814877589