Molecular basis of Drug transport by Multidrug transporters of Candida Albicans

Since, majority of the fungal infections do not infect healthy individuals, their clinical

importance tend to be underappreciated. As for the general public, apart from

dermatophytic infections of the skin and nails, awareness about fungal infections

remains limited. However, with rise in the number of immunocompromised

individuals and use of modern medical devices, invasive fungal infections have

reached staggering numbers. Despite the fact that only a fraction of fungal species are

pathogenic to humans, they are responsible for significant degree of morbidity and

mortality (Pfaller and Diekema 2004; Srinivasan et al. 2014). Most fungal infections

are predominantly caused by Candida, Cryptococcus and Aspergillus species.